A lot of people asked me recently why kinetics in hashtag#drugdiscovery matter (mostly scientists, but some smart investors too! 🤓), so I thought I’d summarise:
Kinetics is crucial in drug discovery because it helps to understand how drugs interact with their targets. Kinetic studies can provide valuable information about the drug’s pharmacological properties, including its potency, selectivity, and duration of action.
Here’s why we place so much value on kinetics at Arctoris:
1️⃣ Predicting drug efficacy: Kinetics can help predict how quickly a drug will bind to its target and how long it will stay bound. This information is critical for determining the drug’s efficacy and optimal dosing regimen.
2️⃣ Optimizing drug design: Kinetic studies can help optimize the design of a drug by providing insights into the relationship between the chemical structure of the drug and its pharmacological properties. For example, knowing the kinetic parameters of a drug can help medicinal chemists design more potent and selective drugs with fewer side effects.
3️⃣ Understanding drug toxicity: Kinetic studies can help identify potential toxicity issues with a drug by revealing how it interacts with other biological molecules and how quickly it is metabolized and eliminated from the body.
4️⃣ Facilitating regulatory approval: Kinetic studies are required by regulatory agencies like the FDA to evaluate the safety and efficacy of new drugs. By providing a detailed understanding of a drug’s pharmacokinetic and pharmacodynamic properties, kinetic studies can help expedite the approval process.
Kinetics are not only intellectually and aesthetically pleasing, but in fact a critical tool in drug discovery that can provide valuable insights into the pharmacological properties of potential drugs, enabling researchers to design safer and more effective treatments for a wide range of diseases. We use hashtag#automation to run these experiments as early as possible in the drug discovery journey so that we can identify and optimise the desired properties from the beginning.
If you want to improve the success of your drug design, get in touch to discuss!
