Hit-to-Lead
Interrogate hits deeply to identify and prioritize true leads with precision.
Capabilities Overview
Biophysics: Detailed kinetic and thermodynamic characterization of binary and ternary systems
Cell Biology: Functional and mechanistic evaluation in disease-relevant systems
Structural Biology: Co-crystallography and cryo-EM to guide medicinal chemistry
Data Science: Rich SAR datasets and ML-integrated feedback loops
Strategic Consulting: Target Molecular Profile (TMP) definition and lead triaging strategy
Value to Your Program
Deeper insights into mechanism of action and selectivity
Early triage of liabilities via multiparametric in vitro data
Predictive, structure-based iteration with shorter synthesis–test cycles
Reduced false positives via orthogonal and context-specific assays
Validation Metrics
Delivered 10-fold potency improvement through structure-guided optimization
Enabled high-content screening extracting >5,700 cellular features per compound
Iterated lead triage loops with 3x speed-up using active learning workflows
Supported clients reducing hit-to-lead timelines by up to 40%