4. Lead Optimization

Optimize efficacy, safety, and developability with integrated multimodal workflows.

Key Capabilities

Biochemistry: Mechanistic and kinetic profiling across concentration ranges

Cutting-Edge Technology: The Ulysses® platform combines state-of-the-art liquid handling with high-end plate readers for exceptional throughput and precision.

Cell Biology: Efficacy and toxicity readouts in complex models (3D, co-culture)

Biophysics: Fine-tuned affinity and residence time analysis

Structural Biology: Iterative ligand co-crystal structures to guide selectivity and potency

Biologics: Engineering and screening of antibodies, bispecifics, and other modalities

Data Science: Custom dashboards tracking potency, exposure, and ADMET data trends

Value to Your Program

Rational, data-driven optimization supported by structural and kinetic insights

Seamless connection between chemical series and cellular phenotypes

Improved confidence in compound prioritization using integrative data

Support for both small molecules and biologics under one roof

Validation Metrics

Reduced lead optimization timelines by up to 30% across multiple programs

High-content assays enabled differentiation of lead series at cellular resolution

Supported >12 biologic candidates advancing toward IND with optimized profiles