3. Hit-to-Lead Optimization
Interrogate hits deeply to identify and prioritize true leads with precision.
Key Capabilities
Biophysics: Detailed kinetic and thermodynamic characterization of binary and ternary systems
Cell Biology: Functional and mechanistic evaluation in disease-relevant systems
Structural Biology: Co-crystallography and cryo-EM to guide medicinal chemistry
Data Science: Rich SAR datasets and ML-integrated feedback loops
Strategic Consulting: Target Molecular Profile (TMP) definition and lead triaging strategy
Value to Your Program
Development and optimization of bespoke biochemical assays
High-throughput screening and profiling of up to 2,000 compounds per day
Orthogonal assay validation for hit confirmation
Quantitative kinetic and thermodynamic profiling
Integration with structural biology for mode-of-action studies
Access to diverse compound libraries through strategic partnerships
Automated data analysis and reporting for rapid insights
Validation Metrics
Delivered 10-fold potency improvement through structure-guided optimization
Enabled high-content screening extracting >5,700 cellular features per compound
Iterated lead triage loops with 3x speed-up using active learning workflows
Supported clients reducing hit-to-lead timelines by up to 40%